fig4

Figure 4. Unaltered cardiac function following long-term genome editing. (A) Representative short-axis M-mode echocardiography images of the left ventricle of R176Q/+ mice treated with control (Con) AAV9 or gRNA-SaCas9, or WT littermate mice, at 4, 8, and 12 months after AAV9 administration. Quantification of (B) ejection fraction, (C) end-diastolic diameter, and (D) left ventricular posterior wall thickness in diastole. P-values based on the one-way ANOVA test followed by Tukey’s post-hoc test.