fig1

Figure 1. Caloric restriction promotes longevity, but preserves circadian robustness and provides maximal lifespan extension when administered during the active phase. (A) Three of the six feeding regimens used to demonstrate the lifespan extension by calorie restriction. Only energy intake at night provided maximal lifespan expansion and maintained circadian robustness. (B) Caloric restriction preserved insulin sensitivity throughout aging, having a protective effect on tissues across the body.