fig1

Figure 1. Replication of mature cardiac myocyte nuclei upon delivery of synthetic modified mRNAs expressing STEMIN and YAP5SA. (A) Transfection of mature cardiac myocytes with constructs expressing modified STEMIN [SRF153(A3) and YAP5SA]. (B) Disassembly of cardiac myocyte sarcomere structure, chromatin remodeling, and reversion to a immature state. (C) Nuclear division generating diploid and tetraploid myocytes.