fig1

Figure 1. Prior work suggested a causative role of PLA2G7 in various cardiovascular diseases (right)^[4,16]. Spadaro et al.^[3] demonstrated caloric restriction reduces PLA2G7 expression and improves immunogenic and metabolic aspects of aging (left). PLA2G7 age-related methylation has been suggested to be a biomarker of cardiovascular aging, though the mechanism is unclear, and PLA2G7 has not been shown to have a causative role in cardiovascular aging^[5].