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Figure 1. Glycoprotein nonmetastatic melanoma protein B (GPNMB) as a vaccine target for senolysis. Suda et al.^[10] utilized RNAseq data on senescent cells to uncover GPNMB as a transmembrane protein disproportionately upregulated in senescent endothelial cells. GPNMB-based vaccination protected mice against vascular plaque burden, and extended lifespan in an accelerated aging model characterized by vascular pathology. Pink cells represent healthy cells; grey cells represent senescent cells; yellow icons represent GPNMB protein that accumulates on aged and senescent endothelial cells; white outlined cells represent eliminated senescent cells from senolytic vaccination.