fig6

Figure 6. Suppression of β-catenin in cardiac myocytes induces genes involved in the mitochondrial OXPHOS pathway. (A) GSEA plots of the DEGs in cardiac myocytes from the Myh6-Mcm:Ctnnb1^LoF mouse (β-catenin suppression) showing activation of genes involved in the mitochondrial OXPHOS as compared to the wild type myocytes. A similar comparison between the Myh6-Mcm:Ctnnb1^LoF and Myh6-Mcm:Ctnnb1^GoF genotypes also shows activation of the OXPHOS pathway in the Myh6-Mcm:Ctnnb1^LoF mouse hearts. (B) RT-PCR validation of the transcript levels of genes involved in mitochondrial OXPHOS pathway in the Myh6-Mcm:Ctnnb1^LoF cardiac myocytes at 4 weeks of age (n = 4-5). GSEA: Gene Set Enrichment Analysis; DEGs: differentially expressed genes; OXPHOS: oxidative phosphorylation; Myh6-Mcm: myosin heavy chain 6-MerCreMer; RT-PCR: reverse transcription-polymerase chain reaction.