fig2

Figure 2. Predicted changes in the regulators of gene expression and biological pathways. (A) Panel A illustrated the transcriptional regulators (TRs), which are predicted to be activated or suppressed based on the number of differentially expressed genes (DEGs). The latter is depicted next to each TR. Red indicated predicted activation and blue predicted suppression. A Z score of < -2 and greater > 2 is considered significant. (B) The list of the biological pathways obtained from the overrepresentation (OR) analysis of the upregulated genes is depicted in the graph, along with the number of DEGs that overlaps with the genes in that pathway. (C) The list of biological pathways was obtained from the OR analysis of the downregulated genes in the Myh6-Mcm myocytes. The number of the DEGs that overlap with the genes in each pathway is listed next to each pathway. (D) Circos plot depicting the predicted activated biological pathways and contribution of the genes to the dysregulated pathways. (E) Gene set enrichment analysis (GSEA) showing enrichment of the genes in the interferon alpha pathway in the Myh6-Mcm myocytes.