fig6

Pharmacological suppression of the WNT signaling pathway attenuates age-dependent expression of the phenotype in a mouse model of arrhythmogenic cardiomyopathy

Figure 6. Effects of suppression of the cWNT pathway on cardiac myocyte size. (A) Representative immunofluorescence panels showing myocardial cells stained with PCM1, which marks the cardiac myocyte nuclei in the heart. (B) Thin myocardial sections stained for Wheat germ agglutinin (WGA), which stains the extra-cellular matrix and cell boundaries. (C) Quantitation of WGA-stained area presented as pixels and corrected for the number of cardiac myocytes; the latter identified by the PCM1 (pericentriolar material 1) expression in the nuclei (N = 4-7). PG: P value for the effect of the genotype; PTr: P value for the effect of treatment; Pi: P value for treatment-by-genotype interaction.

The Journal of Cardiovascular Aging

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