fig2

Pharmacological suppression of the WNT signaling pathway attenuates age-dependent expression of the phenotype in a mouse model of arrhythmogenic cardiomyopathy

Figure 2. Partial rescue of transcript levels of markers of cardiac dysfunction in the Myh6-Cre:DspW/F mice upon suppression of the cWNT. Quantitative RT-PCR data depicting the transcript levels of markers of cardiac dysfunction Nppa (A type natriuretic peptide), Nppb (B-type natriuretic peptide), Acta1 (actin α, skeletal), and Myh6 Myh6 (myosin heavy chain 6) in the wild type and Myh6-Cre:DspW/F mice treated with WNT974 as compared to the untreated and placebo treated mice. PG: P value for the effect of the genotype; PTr: P value for the effect of treatment; Pi: P value for treatment-by-genotype interaction.

The Journal of Cardiovascular Aging

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