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Cardiovascular Aging



  • Lorrie Kirshenbaum, Ph.D.

    Departments of Physiology and Pathophysiology, and Pharmacology and Therapeutics, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Canada.


  • Toren Finkel, M.D., Ph.D.

    Distinguished Professor of Medicine; G. Nicholas Beckwith III and Dorothy B. Beckwith Chair in Translational Medicine; Director, Aging Institute of UPMC and Pitt, Pittsburgh, PA, USA.

    Toren Finkel M.D., Ph.D. is a word renown physician-scientist, who has made seminal discoveries on the role of mitochondria, metabolism, oxidative stress, and autophagy in cardiovascular disease and organismal aging.

    Dr. Finkel received his MD from Harvard Medical School (1986) and Ph.D. in Biophysics, from Harvard University School of Arts & Sciences (1986). He completed training in Medicine at Massachusetts General Hospital and Cardiology at Johns Hopkins Hospital. Upon completion of his training, Dr. Finkel joined the NIH, where he rose to the position of Chief of the Center for Molecular Medicine and Chief of Translational Medicine at the NHLBI. He was recruited in 2017 to UPMC to lead the Aging Institute.

    Dr. Finkel is one of the world's most-cited scientists. Dr. Finkel has published over 250 articles, which have been cited ~ 90,000 times (Google scholar), and has earned him an H index of112 (Google scholar). His work on reactive oxygen species and mitochondria is among the highest cited articles, with several being cited > 3,000. For his scientific contributions, Dr. Finkel has received numerous awards, including NHLBI Orloff Innovation Award (2016), NHLBI Director's Award-Outstanding Translational Science (2015), and Ellison Medical Foundation Senior Scholar in Aging Award (2006-2010). Dr. Finkel has been honored by various institutions and was elected to the National Academy of Medicine (2020), American Association for the Advancement of Science (Fellow 2013), American Society for Clinical Research (2002), and AAP (2009). He serves on the editorial board of several journals, including the JCA, where he is a Consulting Editor.

    The lectureship is named after Nobel Laureate Christian de Duve, M.D., Ph.D., (1974 Physiology or Medicine) who is considered the father of autophagy. Dr. deDuve discovered lysosome in 1955 and defined peroxisomes in 1965.


  • Journal Introduction & Speaker Introduction
  • Lysosomes and aging: Underlying mechanisms and therapeutic potential
  • Discussion (Q&A)
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